Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM285651
Substrate
n/a
Meas. Tech.
Human D1 Receptor Binding Assay
pH
7.4±n/a
Ki
1730±n/a nM
Comments
extracted
Citation
 Gray, DL; Zhang, L; Davoren, JE; Dounay, AB; Efremov, IV; Lee, C; Mente, SR; O Neil, SV; Rogers, BN; Subramanyam, C Heteroaromatic compounds and their use as dopamine D1 ligands US Patent  US10077272 Publication Date 9/18/2018 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM285651
Synonyms:
1,5-dimethyl-6-{2-methyl-4-[(3-methyl[1,2]oxazolo[4,5-c]pyridin-4-yl)oxy]phenyl}pyrazin-2(1H)-one, trifluoroacetic acidsalt | US10077272, Example 17 | US9868744, 17
Type:
Small organic molecule
Emp. Form.:
C20H18N4O3
Mol. Mass.:
362.3819
SMILES:
Cc1noc2ccnc(Oc3ccc(c(C)c3)-c3c(C)ncc(=O)n3C)c12 |(-5.35,-1.5,;-4.95,-2.99,;-5.85,-4.23,;-4.95,-5.48,;-3.48,-5,;-2.15,-5.78,;-.82,-5,;-.82,-3.47,;-2.15,-2.69,;-2.15,-1.15,;-.82,-.38,;.52,-1.15,;1.85,-.38,;1.85,1.15,;.52,1.93,;.52,3.47,;-.82,1.15,;3.19,1.93,;4.52,1.15,;4.52,-.38,;5.85,1.93,;5.85,3.47,;4.52,4.23,;4.52,5.78,;3.19,3.47,;1.85,4.23,;-3.48,-3.47,)|
Structure:
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