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Target
Uridine phosphorylase 1
Ligand
BDBM135803
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
7.3±n/a
Temperature
310.15±n/a K
IC50
<100000±n/a nM
Comments
extracted
Citation
 Garland, WA; Frenzel, BD; Karg, T Methotrexate adjuvants to reduce toxicity and methods for using the same US Patent  US8853227 Publication Date 10/7/2014 
Target
Name:
Uridine phosphorylase 1
Synonyms:
UP | UPP1 | UPP1_HUMAN | UPase 1 | UrdPase 1 | Uridine phosphorylase (UPase)
Type:
Enzyme
Mol. Mass.:
33939.54
Organism:
Homo sapiens (Human)
Description:
Q16831
Residue:
310
Sequence:
MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLSKA
  
Inhibitor
Name:
BDBM135803
Synonyms:
US8853227, TK- 000006 | USRE48253, Designation TK-000006
Type:
Small organic molecule
Emp. Form.:
C16H17N3O5
Mol. Mass.:
331.3233
SMILES:
OC[C@H]1O[C@@H]2[C@@H](Oc3nc(=O)c(NCc4ccccc4)cn23)[C@@H]1O |r|
Structure:
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