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Target
Tyrosine-protein kinase SYK
Ligand
BDBM138215
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assay
Temperature
298.15±n/a K
IC50
6.6±n/a nM
Comments
extracted
Citation
 Choi, J; Hwang, H; Lee, E; Lee, J; Song, H; Kim, SW; Kim, J; Koh, JS; Lee, T; Choi, Y; Han, I; Lee, J; Lee, IY; Jung, DS Substituted pyrimidine compounds and their use as SYK inhibitors US Patent  US8871778 Publication Date 10/28/2014 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM138215
Synonyms:
US8871778, 235
Type:
Small organic molecule
Emp. Form.:
C25H30ClN7O2
Mol. Mass.:
496.004
SMILES:
COC[C@@H]1C[C@@H](O)CN1Cc1cn(nc1C)-c1ccnc(Nc2ccc3n(C)c(C)c(Cl)c3c2)n1 |r|
Structure:
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