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Target
Protein mono-ADP-ribosyltransferase PARP3
Ligand
BDBM138355
Substrate
n/a
Meas. Tech.
Biochemical Assay
Kd
180±n/a nM
Citation
 Papeo, GM; Anatolievna Busel, A; Khvat, A; Krasavin, MY; Forte, B; Zuccotto, F 3-oxo-2,3-dihydro-1H-isoindole-4-carboxamides as PARP inhibitors US Patent  US8877944 Publication Date 11/4/2014 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP3
Synonyms:
Adprt3 | PARP3_MOUSE | Parp3 | Poly [ADP-ribose] polymerase 3 (Parp3)
Type:
Enzyme
Mol. Mass.:
59456.24
Organism:
Mus musculus (Mouse)
Description:
Q8CFB8
Residue:
533
Sequence:
MAPKRKASVQTEGSKKRRQGTEEEDSFRSTAEALRAAPADNRVIRVDPSCPFSRNPGIQVHEDYDCTLNQTNIGNNNNKFYIIQLLEEGSRFFCWNRWGRVGEVGQSKMNHFTCLEDAKKDFKKKFWEKTKNKWEERDRFVAQPNKYTLIEVQGEAESQEAVVKALSPQVYSGPVRTVVKPCSLDPATQNLITNIFSKEMFKNAMTLMNLDVKKMPLGKLTKQQIARGFEALEALEEAMKNPTGDGQSLEELSSCFYTVIPHNFGRSRPPPINSPDVLQAKKDMLLVLADIELAQTLQAAPGEEEEKVEEVPHPLDRDYQLLRCQLQLLDSGESEYKAIQTYLKQTGNSYRCPDLRHVWKVNREGEGDRFQAHSKLGNRRLLWHGTNVAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVTTMHCGGHQVGYMFLGEVALGKEHHITIDDPSLKSPPSGFDSVIARGQTEPDPAQDIELELDGQPVVVPQGPPVQCPSFKSSSFSQSEYLIYKESQCRLRYLLEIHL
  
Inhibitor
Name:
BDBM138355
Synonyms:
US8877944, P1
Type:
Small organic molecule
Emp. Form.:
C41H44N5O3
Mol. Mass.:
654.8192
SMILES:
CN(C)c1ccc2C=c3cc4CCC[N+](CCCC(=O)N(C)CC(=O)Nc5ccc6[nH]c(=O)c7ccccc7c6c5)=c4cc3C(C)(C)c2c1 |c:43,t:7|
Structure:
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