Reaction Details Report a problem with these data
Target
Peptidyl-prolyl cis-trans isomerase B
Ligand
BDBM140000
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.8±n/a
Temperature
293.15±n/a K
IC50
5200±n/a nM
Comments
extracted
Citation
 Guichou, J; Colliandre, L; Ahmed-Belkacem, H; Pawlotsky, J Inhibitors of cyclophilins and uses thereof US Patent  US8901295 Publication Date 12/2/2014 
Target
Name:
Peptidyl-prolyl cis-trans isomerase B
Synonyms:
CYP-S1 | CYPB | Cyclophilin B | Cyclophilin B (CypB) | PPIB | PPIB_HUMAN | PPIase | Peptidyl-prolyl cis-trans isomerase B | Rotamase | S-cyclophilin | SCYLP
Type:
Protein
Mol. Mass.:
23751.82
Organism:
Homo sapiens (Human)
Description:
P23284
Residue:
216
Sequence:
MLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE
  
Inhibitor
Name:
BDBM140000
Synonyms:
US8901295, F587
Type:
Small organic molecule
Emp. Form.:
C20H25N5O3
Mol. Mass.:
383.4442
SMILES:
COc1ccccc1C1CCCN1C(=O)CNC(=O)NCc1ccc(N)nc1
Structure:
Search PDB for entries with ligand similarity: