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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM141341
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
3±n/a
IC50
497±n/a nM
Comments
extracted
Citation
 Caldarelli, M; Casuscelli, F; Donati, D; Mirizzi, D; Quartieri, F; Silvagni, M Tricyclic derivatives, process for their preparation and their use as kinase inhibitors US Patent  US8916577 Publication Date 12/23/2014 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM141341
Synonyms:
US8916577, 5
Type:
Small organic molecule
Emp. Form.:
C34H41N9O3
Mol. Mass.:
623.7478
SMILES:
COc1cc(ccc1Nc1ncc2CCCc3c(nn(C)c3-c2n1)C(=O)N[C@H](CN)c1ccccc1)C(=O)NC1CCN(C)CC1 |r|
Structure:
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