Reaction Details
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Pro-glucagon
Ligand
BDBM142025
Substrate
n/a
Meas. Tech.
SPA Assay
pH
7.4±n/a
Ki
1855±n/a nM
Citation
Didiuk, M; Filipski, KJ; Guzman-Perez, A; Lee, EC; Pfefferkorn, JA; Stevens, B; Tu, M Quinolinyl glucagon receptor modulators US Patent US8927577 Publication Date 1/6/2015 More Info.:
Target
Name:
Pro-glucagon
Synonyms:
GCG | GLUC_HUMAN | Glucagon | Glucagon receptor (GCGR)
Type:
Enzyme
Mol. Mass.:
20907.95
Organism:
Homo sapiens (Human)
Description:
P01275
Residue:
180
Sequence:
MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILDNLAARDFINWLIQTKITDRK
Inhibitor
Name:
BDBM142025
Synonyms:
US8927577, 6
Type:
Small organic molecule
Emp. Form.:
C25H29N3O4
Mol. Mass.:
435.5155
SMILES:
COc1cccc2ccc(NC(CC(C)C)c3ccc(cc3)C(=O)NCCC(O)=O)nc12
Structure:
