Reaction Details
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Pro-glucagon
Ligand
BDBM142048
Substrate
n/a
Meas. Tech.
SPA Assay
pH
7.4±n/a
Ki
930±n/a nM
Citation
Didiuk, M; Filipski, KJ; Guzman-Perez, A; Lee, EC; Pfefferkorn, JA; Stevens, B; Tu, M Quinolinyl glucagon receptor modulators US Patent US8927577 Publication Date 1/6/2015 More Info.:
Target
Name:
Pro-glucagon
Synonyms:
GCG | GLUC_HUMAN | Glucagon | Glucagon receptor (GCGR)
Type:
Enzyme
Mol. Mass.:
20907.95
Organism:
Homo sapiens (Human)
Description:
P01275
Residue:
180
Sequence:
MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILDNLAARDFINWLIQTKITDRK
Inhibitor
Name:
BDBM142048
Synonyms:
US8927577, 29
Type:
Small organic molecule
Emp. Form.:
C22H20F3N3O3
Mol. Mass.:
431.4077
SMILES:
OC(=O)CCNC(=O)c1ccc(cc1)C(CC(F)(F)F)Nc1cnc2ccccc2c1
Structure:
