Reaction Details
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Pro-glucagon
Ligand
BDBM142030
Substrate
n/a
Meas. Tech.
SPA Assay
pH
7.4±n/a
Ki
1237±n/a nM
Citation
Didiuk, M; Filipski, KJ; Guzman-Perez, A; Lee, EC; Pfefferkorn, JA; Stevens, B; Tu, M Quinolinyl glucagon receptor modulators US Patent US8927577 Publication Date 1/6/2015 More Info.:
Target
Name:
Pro-glucagon
Synonyms:
GCG | GLUC_HUMAN | Glucagon | Glucagon receptor (GCGR)
Type:
Enzyme
Mol. Mass.:
20907.95
Organism:
Homo sapiens (Human)
Description:
P01275
Residue:
180
Sequence:
MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILDNLAARDFINWLIQTKITDRK
Inhibitor
Name:
BDBM142030
Synonyms:
US8927577, 11 | US8927577, 30 | US8927577, 31
Type:
Small organic molecule
Emp. Form.:
C25H29N3O3
Mol. Mass.:
419.5161
SMILES:
CC(C)CC(Nc1nc2ccccc2cc1C)c1ccc(cc1)C(=O)NCCC(O)=O
Structure:
