Reaction Details Report a problem with these data
Target
Aurora kinase B-B
Ligand
BDBM142739
Substrate
n/a
Meas. Tech.
Radioactive Kinase Assay
pH
7.6±n/a
IC50
2±n/a nM
Comments
extracted
Citation
 Zahn, SK; Sini, P; Bister, B Anticancer compounds US Patent  US8937095 Publication Date 1/20/2015 
Target
Name:
Aurora kinase B-B
Synonyms:
AUKBB_XENLA | Aurora kinase B | airk2-b | aurkb-b
Type:
Protein
Mol. Mass.:
42037.56
Organism:
Xenopus laevis (African clawed frog)
Description:
Q6GPL3
Residue:
368
Sequence:
MSYKENLIPSSCSSSSSSSSKFATPSSATAAQRVLRKQPYVSIFTTPSDNLLAQRAQLAPRVTPAASSSVPGRVALGTDVASHNTALAEAPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALQYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHSETHRRIVNVDLKFPPFLSEGSKDLISKLLRYHPAQRLPLKGVMEHPWVKANSRRVLPPVYQSSHPK
  
Inhibitor
Name:
BDBM142739
Synonyms:
US8937095, 1
Type:
Small organic molecule
Emp. Form.:
C31H31N5O2
Mol. Mass.:
505.6101
SMILES:
CCNC(=O)C#Cc1ccc2\C(=C(\Nc3ccc(cc3)N3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Structure:
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