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Target
Aurora kinase B-B
Ligand
BDBM142740
Substrate
n/a
Meas. Tech.
Radioactive Kinase Assay
pH
7.6±n/a
IC50
7±n/a nM
Comments
extracted
Citation
 Zahn, SK; Sini, P; Bister, B Anticancer compounds US Patent  US8937095 Publication Date 1/20/2015 
Target
Name:
Aurora kinase B-B
Synonyms:
AUKBB_XENLA | Aurora kinase B | airk2-b | aurkb-b
Type:
Protein
Mol. Mass.:
42037.56
Organism:
Xenopus laevis (African clawed frog)
Description:
Q6GPL3
Residue:
368
Sequence:
MSYKENLIPSSCSSSSSSSSKFATPSSATAAQRVLRKQPYVSIFTTPSDNLLAQRAQLAPRVTPAASSSVPGRVALGTDVASHNTALAEAPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALQYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHSETHRRIVNVDLKFPPFLSEGSKDLISKLLRYHPAQRLPLKGVMEHPWVKANSRRVLPPVYQSSHPK
  
Inhibitor
Name:
BDBM142740
Synonyms:
US8937095, 2
Type:
Small organic molecule
Emp. Form.:
C29H26F2N4O2
Mol. Mass.:
500.5391
SMILES:
CN(C)Cc1ccc(N\C(=C2/C(=O)Nc3cc(ccc23)C#CC(=O)NCC(F)F)c2ccccc2)cc1
Structure:
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