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Target
Tyrosine-protein kinase BTK
Ligand
BDBM143320
Substrate
n/a
Meas. Tech.
HTRF Assay
IC50
0.87±n/a nM
Citation
 Bosanac, T; Disalvo, D; Horan, JC; Liang, S; Zindell, RM Heteroaromatic compounds as BTK inhibitors US Patent  US8940893 Publication Date 1/27/2015 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM143320
Synonyms:
US8940893, 5
Type:
Small organic molecule
Emp. Form.:
C27H26N6O2
Mol. Mass.:
466.5343
SMILES:
Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CC2(C1)CCN(C2)C(=O)C=C |(3.23,-2.27,;1.69,-2.27,;.92,-3.61,;-.62,-3.61,;-1.39,-2.27,;-.62,-.94,;-1.1,.53,;.15,1.43,;1.39,.53,;2.72,1.3,;2.72,2.84,;4.06,3.61,;5.39,2.84,;6.73,3.61,;8.06,2.84,;9.39,3.61,;10.73,2.84,;10.73,1.3,;9.39,.53,;8.06,1.3,;5.39,1.3,;4.06,.53,;.92,-.94,;-2.59,.92,;-3.36,2.26,;-4.69,1.49,;-3.92,.15,;-5.6,2.73,;-7.06,2.26,;-7.06,.72,;-5.6,.24,;-8.15,-.37,;-7.75,-1.86,;-9.64,.03,;-10.73,-1.06,)|
Structure:
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