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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM149685
Substrate
n/a
Meas. Tech.
Trans-Phosphorylation Assay
pH
3±n/a
IC50
748±n/a nM
Comments
extracted
Citation
 Caldarelli, M; Angiolini, M; Beria, I; Brasca, MG; Casuscelli, F; D'Alessio, R; Lombardi Borgia, A Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors US Patent  US8975267 Publication Date 3/10/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM149685
Synonyms:
US8975267, 7
Type:
Small organic molecule
Emp. Form.:
C25H31N7O2
Mol. Mass.:
461.5593
SMILES:
COc1cc(ccc1Nc1ncc2CCc3c(C(N)=O)c(C)n(C)c3-c2n1)N1CCN(C)CC1
Structure:
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