Reaction Details
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Sphingosine 1-phosphate receptor 2
Ligand
BDBM149705
Substrate
n/a
Meas. Tech.
Fluorescence-Based Assay
pH
7.2±n/a
Temperature
310.15±n/a K
IC50
3.3±n/a nM
Comments
extracted
Citation
Naganawa, A; Kusumi, K; Otsuki, K; Sekiguchi, T; Kakuuchi, A; Shinozaki, K; Yamamoto, H; Nonaka, S Phenyl derivative US Patent US8975409 Publication Date 3/10/2015 More Info.:
Target
Name:
Sphingosine 1-phosphate receptor 2
Synonyms:
Edg5 | S1PR2_RAT | S1pr2 | Sphingosine 1-phosphate receptor 2 (S1P2)
Type:
Protein
Mol. Mass.:
38749.58
Organism:
Rattus norvegicus (Rat)
Description:
P47752
Residue:
352
Sequence:
MGGLYSEYLNPEKVQEHYNYTKETLDMQETPSRKVASAFIIILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGPVTLSLTPLQWFAREGSAFITLSASVFSLLAIAIERQVAIAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCLDHLEACSTVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSSHADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVLRPLLCWRQGKGATGRRGGNPGHRLLPLRSSSSLERGLHMPTSPTFLEGNTVV
Inhibitor
Name:
BDBM149705
Synonyms:
US8975409, Example 9(3)
Type:
Small organic molecule
Emp. Form.:
C31H26F2N2O6
Mol. Mass.:
560.5447
SMILES:
OC(=O)c1ccc(Oc2cc(NC(=O)N3CCC(O)(CC3)c3ccc(F)cc3)cc(Oc3ccc(F)cc3)c2)cc1
Structure:
