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Target
Uncharacterized protein
Ligand
BDBM286289
Substrate
n/a
Meas. Tech.
Luminescent Kinase Assay
IC50
5.00±n/a nM
Citation
 Fan, E; Van Voorhis, WC; Zhang, Z; Huang, W; Ojo, KK 5-aminopyrazole-4-carboxamide inhibitors of CDPK1 from T. gondii and C. parvum US Patent  US9518026 Publication Date 12/13/2016 
Target
Name:
Uncharacterized protein
Synonyms:
Calmodulin-domain protein kinase (CDPK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60946.72
Organism:
Cryptosporidium parvum
Description:
n/a
Residue:
538
Sequence:
MGNTAVGNTGTRLRAPVDAVVNTTNKKAPVSEKPSQPQIPNKTSDVKKGGTMGGERGSVTTGMFVQSGSGTFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSETPTISDLPSLESAMTNIRQFQAEKKLAQAALLYMASKLTTLDETKQLTEIFRKLDTNNDGMLDRDELVRGYHEFMRLKGVDSNSLIQNEGSTIEDQIDSLMPLLDMDGSGSIEYSEFIASAIDRTILLSRERMERAFKMFDKDGSGKISTKELFKLFSQADSSIQMEELESIIEQVDNNKDGEVDFNEFVEMLQNFVRNE
  
Inhibitor
Name:
BDBM286289
Synonyms:
5-amino-1-(tert-butyl)-3-(7-(2- methoxyethoxy)quinolin-3-yl)- 1H-pyrazole-4-carboxamide MS (ESI) (M + H)+ = 384.5 | US9518026, Example 82 | US9956214, Compound 1570
Type:
Small organic molecule
Emp. Form.:
C20H25N5O3
Mol. Mass.:
383.4442
SMILES:
COCCOc1ccc2cc(cnc2c1)-c1nn(c(N)c1C(N)=O)C(C)(C)C
Structure:
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