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Target
Acetylcholinesterase
Ligand
BDBM150746
Substrate
n/a
Meas. Tech.
Ellman's Method
IC50
7.19e+4± 7.2e+3 nM
Citation
 Krátký, M; ?tepánková, ÿ¿ÿ ; Vorcáková, K; Vin?ová, J Salicylanilide diethyl phosphates as cholinesterases inhibitors. Bioorg Chem 58:48-52 (2015) [PubMed]  Article 
Target
Name:
Acetylcholinesterase
Synonyms:
ACES_ELEEL | Acetylcholinesterase (AChE) | Acetylcholinesterase (EeAChE) | ache
Type:
Enzyme
Mol. Mass.:
71812.79
Organism:
Electrophorus electricus (Electric eel)
Description:
n/a
Residue:
633
Sequence:
MKILDALLFPVIFIMFFIHLSIAQTDPELTIMTRLGQVQGTRLPVPDRSHVIAFLGIPFAEPPLGKMRFKPPEPKKPWNDVFDARDYPSACYQYVDTSYPGFSGTEMWNPNRMMSEDCLYLNVWVPATPRPHNLTVMVWIYGGGFYSGSSSLDVYDGRYLAHSEKVVVVSMNYRVSAFGFLALNGSAEAPGNVGLLDQRLALQWVQDNIHFFGGNPKQVTIFGESAGAASVGMHLLSPDSRPKFTRAILQSGVPNGPWRTVSFDEARRRAIKLGRLVGCPDGNDTDLIDCLRSKQPQDLIDQEWLVLPFSGLFRFSFVPVIDGVVFPDTPEAMLNSGNFKDTQILLGVNQNEGSYFLIYGAPGFSKDNESLITREDFLQGVKMSVPHANEIGLEAVILQYTDWMDEDNPIKNREAMDDIVGDHNVVCPLQHFAKMYAQYSILQGQTGTASQGNLGWGNSGSASNSGNSQVSVYLYMFDHRASNLVWPEWMGVIHGYEIEFVFGLPLEKRLNYTLEEEKLSRRMMKYWANFARTGNPNINVDGSIDSRRRWPVFTSTEQKHVGLNTDSLKVHKGLKSQFCALWNRFLPRLLNVTENIDDAERQWKAEFHRWSSYMMHWKNQFDHYSKQERCTNL
  
Inhibitor
Name:
BDBM150746
Synonyms:
5-chloro-2-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl diethyl phosphate (26)
Type:
Small organic molecule
Emp. Form.:
C18H18ClF3NO5P
Mol. Mass.:
451.761
SMILES:
CCOP(=O)(OCC)Oc1cc(Cl)ccc1C(=O)Nc1cccc(c1)C(F)(F)F
Structure:
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