Reaction Details Report a problem with these data
Target
Peptidoglycan-N-acetylglucosamine deacetylase
Ligand
BDBM150807
Substrate
n/a
Meas. Tech.
Fluorescamine Assay
pH
7±n/a
Temperature
298.15±n/a K
Ki
8.0e+4± 2.0e+4 nM
Comments
extracted
Citation
 Ariyakumaran, R; Pokrovskaya, V; Little, DJ; Howell, PL; Nitz, M Direct Staudinger-Phosphonite Reaction Provides Methylphosphonamidates as Inhibitors of CE4 De-N-acetylases. Chembiochem 16:1350-6 (2015) [PubMed]  Article 
Target
Name:
Peptidoglycan-N-acetylglucosamine deacetylase
Synonyms:
PGDA_STRR6 | Peptidoglycan de-N-acetylase (PgdA) | pgdA
Type:
Protein
Mol. Mass.:
52665.99
Organism:
Streptococcus pneumoniae (Firmicutes)
Description:
Q8DP63
Residue:
463
Sequence:
MNKSRLGRGRHGKTRHVLLALIGILAISICLLGGFIAFKIYQQKSFEQKIESLKKEKDDQLSEGNQKEHFRQGQAEVIAYYPLQGEKVISSVRELINQDVKDKLESKDNLVFYYTEQEESGLKGVVNRNVTKQIYDLVAFKIEETEKTSLGKVHLTEDGQPFTLDQLFSDASKAKEQLIKELTSFIEDKKIEQDQSEQIVKNFSDQDLSAWNFDYKDSQIILYPSPVVENLEEIALPVSAFFDVIQSSYLLEKDAALYQSYFDKKHQKVVALTFDDGPNPATTPQVLETLAKYDIKATFFVLGKNVSGNEDLVKRIKSEGHVVGNHSWSHPILSQLSLDEAKKQITDTEDVLTKVLGSSSKLMRPPYGAITDDIRNSLDLSFIMWDVDSLDWKSKNEASILTEIQHQVANGSIVLMHDIHSPTVNALPRVIEYLKNQGYTFVTIPEMLNTRLKAHELYYSRDE
  
Inhibitor
Name:
BDBM150807
Synonyms:
Sodium N-methylphosphate-1,4-di-O-benzyl-beta-D-glucosamine (15c)
Type:
Small organic molecule
Emp. Form.:
C21H27NNaO7P
Mol. Mass.:
459.4051
SMILES:
[Na+].CP([O-])(=O)N[C@H]1C(O)[C@H](OCc2ccccc2)C(CO)O[C@H]1OCc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: