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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM151905
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.01±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM151905
Synonyms:
US8987457, 99
Type:
Small organic molecule
Emp. Form.:
C30H33F3N4O3
Mol. Mass.:
554.6032
SMILES:
CO[C@H]1[C@@H](C)C[C@H](C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(cc1F)C1CCOCC1 |r,wU:6.10,8.9,3.3,2.1,(-2,2.69,;-3.33,1.93,;-3.33,.38,;-2,-.38,;-.67,.39,;-2,-1.92,;-3.33,-2.69,;-4.67,-1.92,;-4.67,-.38,;-6,.39,;-3.33,-4.23,;-4.67,-5,;-4.67,-6.54,;-3.33,-7.31,;-2,-6.54,;-2,-5,;-.67,-4.23,;.67,-5,;.67,-6.54,;2,-4.23,;3.33,-5,;4.67,-4.23,;4.67,-2.69,;6,-1.92,;3.33,-1.93,;2,-2.69,;3.33,-.38,;2,.38,;.67,-.38,;2,1.93,;3.33,2.69,;4.67,1.93,;4.67,.38,;6,-.38,;3.33,4.23,;4.67,5,;4.67,6.54,;3.33,7.31,;2,6.54,;2,5,)|
Structure:
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