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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM151924
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.02±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM151924
Synonyms:
US8987457, 118
Type:
Small organic molecule
Emp. Form.:
C32H37F3N4O6S
Mol. Mass.:
662.72
SMILES:
C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCS(C)(=O)=O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOCC1 |r,wU:3.15,5.5,1.0,7.8,(.1,.39,;-1.23,-.38,;-1.23,-1.92,;-2.56,-2.69,;-3.9,-1.92,;-3.9,-.38,;-5.23,.39,;-2.56,.38,;-2.56,1.93,;-3.9,2.69,;-3.9,4.23,;-5.23,5,;-5.23,6.54,;-6.77,5,;-6,3.67,;-2.56,-4.23,;-3.9,-5,;-3.9,-6.54,;-2.56,-7.31,;-1.23,-6.54,;-1.23,-5,;.1,-4.23,;1.44,-5,;1.44,-6.54,;2.77,-4.23,;4.1,-5,;5.44,-4.23,;5.44,-2.69,;6.77,-1.92,;4.1,-1.93,;2.77,-2.69,;4.1,-.38,;2.77,.38,;1.44,-.38,;2.77,1.93,;4.1,2.69,;5.44,1.93,;5.44,.38,;6.77,-.38,;4.1,4.23,;5.44,3.47,;5.44,5,;5.44,6.54,;4.1,7.31,;2.77,6.54,;2.77,5,)|
Structure:
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