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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM151943
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.02±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM151943
Synonyms:
US8987457, 137
Type:
Small organic molecule
Emp. Form.:
C30H33F3N4O4
Mol. Mass.:
570.6026
SMILES:
CO[C@@H]1[C@@H](C)C[C@H](C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC2CCOCC2)cc1F |r,wU:6.10,3.3,8.9,wD:2.1,(-5.33,2.69,;-4,1.93,;-4,.38,;-2.67,-.38,;-1.33,.38,;-2.67,-1.93,;-4,-2.69,;-5.33,-1.93,;-5.33,-.38,;-6.67,.38,;-4,-4.23,;-5.33,-5,;-5.33,-6.54,;-4,-7.31,;-2.67,-6.54,;-2.67,-5,;-1.33,-4.23,;,-5,;,-6.54,;1.33,-4.23,;2.67,-5,;4,-4.23,;4,-2.69,;5.33,-1.92,;2.67,-1.93,;1.33,-2.69,;2.67,-.38,;1.33,.38,;,-.38,;1.33,1.93,;2.67,2.69,;2.67,4.23,;4,5,;5.33,4.24,;6.67,5,;6.67,6.54,;5.33,7.31,;4,6.54,;4,1.93,;4,.38,;5.33,-.38,)|
Structure:
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