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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM151945
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.02±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM151945
Synonyms:
US8987457, 139
Type:
Small organic molecule
Emp. Form.:
C31H35F3N4O5S
Mol. Mass.:
632.694
SMILES:
C[C@H]1C[C@H](C[C@@H](N)[C@@H]1OCCS(C)(=O)=O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCC1 |r,wU:3.15,1.0,5.5,wD:7.8,(-.2,.84,;-1.53,.07,;-1.53,-1.47,;-2.87,-2.24,;-4.2,-1.47,;-4.2,.07,;-5.53,.84,;-2.87,.84,;-2.87,2.38,;-4.2,3.15,;-3.8,4.63,;-5.14,5.4,;-6.47,4.63,;-5.91,6.74,;-4.37,6.74,;-2.87,-3.78,;-4.2,-4.55,;-4.2,-6.09,;-2.87,-6.86,;-1.53,-6.09,;-1.53,-4.55,;-.2,-3.78,;1.13,-4.55,;1.13,-6.09,;2.47,-3.78,;3.8,-4.55,;5.14,-3.78,;5.14,-2.24,;6.47,-1.47,;3.8,-1.47,;2.47,-2.24,;3.8,.07,;2.47,.84,;1.13,.07,;2.47,2.38,;3.8,3.15,;5.14,2.38,;5.14,.84,;6.47,.07,;3.8,4.69,;5.14,3.92,;4.89,5.78,;3.8,6.86,;2.71,5.78,)|
Structure:
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