Reaction Details Report a problem with these data
Target
Proteinase-activated receptor 4
Ligand
BDBM286495
Substrate
n/a
Meas. Tech.
FLIPR Assay
Temperature
298.15±n/a K
IC50
0.310±n/a nM
Comments
extracted
Citation
Martel, A; Tremblay, F; Marinier, A; Priestley, ES; Posy, SL; Lawrence, RM; Miller, MM Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation US Patent US9518064 Publication Date 12/13/2016
More Info.:
Target
Name:
Proteinase-activated receptor 4
Synonyms:
Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:
Protein
Mol. Mass.:
41145.16
Organism:
Homo sapiens (Human)
Description:
Q96RI0
Residue:
385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
Inhibitor
Name:
BDBM286495
Synonyms:
(S)-2-(1-Fluoroethyl)-6-(4-((6-(4-fluorotetrahydro-2H-pyran-4-yl)pyridin-2-yl)methoxy)-6-methoxybenzo-furan-2-yl)imidazo[2,1-b][1,3,4]thiadiazole | US9518064, Example 114
Type:
Small organic molecule
Emp. Form.:
C26H24F2N4O4S
Mol. Mass.:
526.555
SMILES:
COc1cc(OCc2cccc(n2)C2(F)CCOCC2)c2cc(oc2c1)-c1cn2nc(sc2n1)[C@H](C)F |r|