Reaction Details Report a problem with these data
Target
Oligo-1,6-glucosidase IMA1
Ligand
BDBM152626
Substrate
n/a
Meas. Tech.
Alpha-glucosidase Assay
pH
6.8±n/a
IC50
1.9355e+5± 4.1e+2 nM
Comments
extracted
Citation
 Rahim, F; Ullah, H; Javid, MT; Wadood, A; Taha, M; Ashraf, M; Shaukat, A; Junaid, M; Hussain, S; Rehman, W; Mehmood, R; Sajid, M; Khan, MN; Khan, KM Synthesis, in vitro evaluation and molecular docking studies of thiazole derivatives as new inhibitors of a-glucosidase. Bioorg Chem 62:15-21 (2015) [PubMed]  Article 
Target
Name:
Oligo-1,6-glucosidase IMA1
Synonyms:
α-glucosidase | Alpha-glucosidase | Alpha-glucosidase (α-glucosidase) | IMA1 | MALX3_YEAST | Oligo-1,6-glucosidase
Type:
Protein
Mol. Mass.:
68577.59
Organism:
Saccharomyces cerevisiae S288c (Baker's yeast)
Description:
n/a
Residue:
589
Sequence:
MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
  
Inhibitor
Name:
BDBM152626
Synonyms:
(E)-4-(4-Methoxyphenyl)-2-(2-(naphthalen-2-yl-methylene)-hydrazinyl)thiazole (15)
Type:
Small organic molecule
Emp. Form.:
C21H17N3OS
Mol. Mass.:
359.444
SMILES:
COc1ccc(cc1)-c1csc(N\N=C\c2ccc3ccccc3c2)n1
Structure:
Search PDB for entries with ligand similarity: