Reaction Details Report a problem with these data
Target
Acetyltransferase, GNAT family
Ligand
BDBM152707
Substrate
n/a
Meas. Tech.
Eis Ban Inhibition Assay
pH
8±n/a
IC50
>2.00e+5±n/a nM
Comments
extracted
Citation
 Green, KD; Biswas, T; Chang, C; Wu, R; Chen, W; Janes, BK; Chalupska, D; Gornicki, P; Hanna, PC; Tsodikov, OV; Joachimiak, A; Garneau-Tsodikova, S Biochemical and structural analysis of an Eis family aminoglycoside acetyltransferase from bacillus anthracis. Biochemistry 54:3197-206 (2015) [PubMed]  Article 
Target
Name:
Acetyltransferase, GNAT family
Synonyms:
Eis_Ban acetyltransferase (Eis_Ban)
Type:
Protein
Mol. Mass.:
45469.21
Organism:
Bacillus anthracis str. Sterne
Description:
Q81P65
Residue:
385
Sequence:
MNVIRLKEDKFREALRLSEYAFQYKVDEDRLQQQITKMKESHEVYGIMEGENLAAKLHLIPFHIYIGKEKFKMGGVAGVATYPEYRRSGYVKELLQHSLQTMKKDGYTVSMLHPFAVSFYRKYGWELCANLLVCHMTKSDLVMKKQVNGTVKRFNKESHPEEVEKLYETFAELFSGMLVRNEKWWLQAVYDDLTLAIYYDENQTAAGYMLYKIENYKMTVEEFVPLHNEARNGLWNFICQHDSMIKDLEMTVSENEPLLYTLQEPRVKTEIKPYFMGRIVDVEQFLKQYELNWNNVQQEVILHITDSFAQWNNITVRIANHEITIIEEPIDKGIKLDINALSTILFGYRRPLELNELELISGSEEEIRAFESVVPVRKPFIYDFF
  
Inhibitor
Name:
BDBM152707
Synonyms:
Methyl 4-(6-bromo-2H-1,3-benzodioxol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate (2)
Type:
Small organic molecule
Emp. Form.:
C15H14BrNO5
Mol. Mass.:
368.179
SMILES:
COC(=O)C1=C(C)NC(=O)CC1c1cc2OCOc2cc1Br |c:4|
Structure:
Search PDB for entries with ligand similarity: