Reaction Details Report a problem with these data
Target
Nitric oxide synthase oxygenase
Ligand
BDBM152710
Substrate
n/a
Meas. Tech.
Imidazole Spin Shift Assay
Kd
2.33e+4± 2.2e+3 nM
Citation
 Holden, JK; Dejam, D; Lewis, MC; Huang, H; Kang, S; Jing, Q; Xue, F; Silverman, RB; Poulos, TL Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase. Biochemistry 54:4075-82 (2015) [PubMed]  Article 
Target
Name:
Nitric oxide synthase oxygenase
Synonyms:
NOSO_BACSU | Nitric oxide synthase (bsNOS) | nos | yflM
Type:
Protein
Mol. Mass.:
41892.66
Organism:
Bacillus subtilis (Firmicutes)
Description:
O34453
Residue:
363
Sequence:
MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGSYVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATNNGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGWRGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPIISDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLWKDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPISPAATHIFHRSYDNSIVKPNYFYQDKPYE
  
Inhibitor
Name:
BDBM152710
Synonyms:
6-({[(1R,3R)-3-[(6-amino-4-methylpyridin-2-yl)methoxy]cyclopentyl]methoxy}methyl)-4-methylpyridin-2-amine (11)
Type:
Small organic molecule
Emp. Form.:
C20H28N4O2
Mol. Mass.:
356.4619
SMILES:
Cc1cc(N)nc(COC[C@@H]2CC[C@H](C2)OCc2cc(C)cc(N)n2)c1 |r|
Structure:
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