Reaction Details Report a problem with these data
Target
Nitric oxide synthase oxygenase
Ligand
BDBM152712
Substrate
n/a
Meas. Tech.
Imidazole Spin Shift Assay
Kd
5.76e+4± 8.7e+3 nM
Citation
 Holden, JK; Dejam, D; Lewis, MC; Huang, H; Kang, S; Jing, Q; Xue, F; Silverman, RB; Poulos, TL Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase. Biochemistry 54:4075-82 (2015) [PubMed]  Article 
Target
Name:
Nitric oxide synthase oxygenase
Synonyms:
NOSO_BACSU | Nitric oxide synthase (bsNOS) | nos | yflM
Type:
Protein
Mol. Mass.:
41892.66
Organism:
Bacillus subtilis (Firmicutes)
Description:
O34453
Residue:
363
Sequence:
MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGSYVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATNNGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGWRGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPIISDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLWKDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPISPAATHIFHRSYDNSIVKPNYFYQDKPYE
  
Inhibitor
Name:
BDBM152712
Synonyms:
4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amino}pyridin-3-yl)ethyl]pyridin-2-amine (14) | US10759791, Compound 5 | US9951014, Name 14b | nNOS inhibitor, 2
Type:
Small organic molecule
Emp. Form.:
C17H25N5
Mol. Mass.:
299.4139
SMILES:
CNCCN(C)c1cncc(CCc2cc(C)cc(N)n2)c1
Structure:
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