Reaction Details Report a problem with these data
Target
Streptopain
Ligand
BDBM152724
Substrate
n/a
Meas. Tech.
SpeB and Papain Kinetic Assay
pH
7.4±n/a
Ki
8e+3± 4e+2 nM
IC50
1.4e+4± 1e+3 nM
Comments
extracted
Citation
 Wang, AY; González-Páez, GE; Wolan, DW Identification and Co-complex Structure of a New S. pyogenes SpeB Small Molecule Inhibitor. Biochemistry 54:4365-73 (2015) [PubMed]  Article 
Target
Name:
Streptopain
Synonyms:
Cysteine protease SpeB (SpeB) | SPEB_STRPY | speB
Type:
Protein
Mol. Mass.:
43181.36
Organism:
Streptococcus pyogenes (Firmicutes)
Description:
P0C0J0
Residue:
398
Sequence:
MNKKKLGIRLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARSAEDIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASFMESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP
  
Inhibitor
Name:
BDBM152724
Synonyms:
2477
Type:
Small organic molecule
Emp. Form.:
C10H10N2O2
Mol. Mass.:
190.1986
SMILES:
O=C(NCC#N)OCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: