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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50236898
Substrate
n/a
Meas. Tech.
In vitro MAOA and MAOB Inhibition Assay
Temperature
298.15±n/a K
IC50
8.51±n/a nM
Comments
extracted
Citation
 Zhou, C; Kang, D; Xu, Y; Zhang, L; Zha, X Identification of Novel Selective Lysine-Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore-Based Virtual Screening Combined with Docking. Chem Biol Drug Des 85:659-71 (2015) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM50236898
Synonyms:
(1S,2R)-(+)-2-phenylcyclopropylamine | CHEMBL257990 | TRANYLCYPROMINE | Tranylcypromine (TCP) | trans-2-phenylcyclopropanamine | trans-2-phenylcyclopropylamine
Type:
Small organic molecule
Emp. Form.:
C9H11N
Mol. Mass.:
133.1903
SMILES:
N[C@H]1C[C@@H]1c1ccccc1 |r|
Structure:
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