Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase receptor UFO
Ligand
BDBM153652
Substrate
n/a
Meas. Tech.
Binding Assay
pH
8±n/a
IC50
8503±n/a nM
Comments
extracted
Citation
 Schultz-Fademrecht, C; Klebl, B; Choidas, A; Koch, U; Eickhoff, J; Wolf, A; Ullrich, A Pharmaceutically active compounds as Axl inhibitors US Patent  US8999982 Publication Date 4/7/2015 
Target
Name:
Tyrosine-protein kinase receptor UFO
Synonyms:
AXL | AXL oncogene | TEL/AXL | Tyrosine-protein kinase receptor UFO (AXL) | UFO | UFO_HUMAN
Type:
Enzyme
Mol. Mass.:
98316.97
Organism:
Homo sapiens (Human)
Description:
P30530
Residue:
894
Sequence:
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
  
Inhibitor
Name:
BDBM153652
Synonyms:
US8999982, 3-fluoro-4-((6-methoxy-7-(3- morpholinopropoxy)quinolin- 4-yl)oxy)aniline
Type:
Small organic molecule
Emp. Form.:
C23H26FN3O4
Mol. Mass.:
427.4686
SMILES:
COc1cc2c(Oc3ccc(N)cc3F)ccnc2cc1OCCCN1CCOCC1
Structure:
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