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Target
Tyrosine-protein kinase JAK2
Ligand
BDBM153663
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.2±n/a
Ki
1±n/a nM
Comments
extracted
Citation
 Gibbons, P; Hanan, E; Liu, W; Lyssikatos, JP; Magnuson, SR; Mendonca, R; Pastor, R; Rawson, TE; Siu, M; Zak, M; Zhou, A; Zhu, B Pyrazolopyrimidine JAK inhibitor compounds and methods US Patent  US8999998 Publication Date 4/7/2015 
Target
Name:
Tyrosine-protein kinase JAK2
Synonyms:
JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase)
Type:
Protein
Mol. Mass.:
130684.68
Organism:
Homo sapiens (Human)
Description:
O60674
Residue:
1132
Sequence:
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM153663
Synonyms:
US8999998, 109
Type:
Small organic molecule
Emp. Form.:
C19H17ClN6O3
Mol. Mass.:
412.83
SMILES:
COc1ccc(Cl)cc1-c1c(NC(=O)c2cnn3cccnc23)cnn1CCO |(1.2,-5.39,;.43,-4.06,;1.2,-2.73,;2.74,-2.73,;3.51,-1.39,;2.74,-.06,;3.51,1.27,;1.2,-.06,;.43,-1.39,;-1.11,-1.39,;-2.02,-.15,;-1.25,1.19,;-2.02,2.52,;-3.51,2.12,;-1.25,3.85,;-2.15,5.1,;-1.25,6.35,;.22,5.87,;1.55,6.64,;2.88,5.87,;2.88,4.33,;1.55,3.56,;.22,4.33,;-3.48,-.62,;-3.48,-2.16,;-2.02,-2.64,;-1.25,-3.97,;-2.02,-5.31,;-1.25,-6.64,)|
Structure:
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