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Target
Platelet-activating factor acetylhydrolase IB subunit alpha2
Ligand
BDBM154535
Substrate
n/a
Meas. Tech.
Competitive ABPP Assays in Proteomes with FP-alkyne
pH
7.5±n/a
IC50
2.0e+3±n/a nM
Comments
extracted
Citation
 Chang, JW; Zuhl, AM; Speers, AE; Niessen, S; Brown, SJ; Mulvihill, MM; Fan, YC; Spicer, TP; Southern, M; Scampavia, L; Fernandez-Vega, V; Dix, MM; Cameron, MD; Hodder, PS; Rosen, H; Nomura, DK; Kwon, O; Hsu, KL; Cravatt, BF Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. ACS Chem Biol 10:925-32 (2015) [PubMed]  Article 
Target
Name:
Platelet-activating factor acetylhydrolase IB subunit alpha2
Synonyms:
PA1B2_MOUSE | Pafah1b2 | Pafahb | Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)
Type:
Protein
Mol. Mass.:
25577.50
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
229
Sequence:
MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWRELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEAIVQLINTRQPQAKIIVLGLLPRGEKPNPLRQKNAKVNQLLKVSLPKLANVQLLDIDGGFVHSDGAISCHDMFDFLHLTGGGYAKICKPLHELIMQLLEETPEEKQTTIA
  
Inhibitor
Name:
BDBM154535
Synonyms:
2-(4-fluorophenyl)-1-(4-methylbenzenesulfonyl)-6-(4-methylphenyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid (O8)
Type:
Small organic molecule
Emp. Form.:
C26H24FNO4S
Mol. Mass.:
465.536
SMILES:
Cc1ccc(cc1)C1CC=C(C(N1S(=O)(=O)c1ccc(C)cc1)c1ccc(F)cc1)C(O)=O |c:10|
Structure:
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