Reaction Details Report a problem with these data
Target
Platelet-activating factor acetylhydrolase IB subunit alpha2
Ligand
BDBM154542
Substrate
n/a
Meas. Tech.
Competitive ABPP Assays in Proteomes with FP-alkyne
pH
7.5±n/a
IC50
4.6e+3±n/a nM
Comments
extracted
Citation
 Chang, JW; Zuhl, AM; Speers, AE; Niessen, S; Brown, SJ; Mulvihill, MM; Fan, YC; Spicer, TP; Southern, M; Scampavia, L; Fernandez-Vega, V; Dix, MM; Cameron, MD; Hodder, PS; Rosen, H; Nomura, DK; Kwon, O; Hsu, KL; Cravatt, BF Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. ACS Chem Biol 10:925-32 (2015) [PubMed]  Article 
Target
Name:
Platelet-activating factor acetylhydrolase IB subunit alpha2
Synonyms:
PA1B2_MOUSE | Pafah1b2 | Pafahb | Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)
Type:
Protein
Mol. Mass.:
25577.50
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
229
Sequence:
MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWRELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEAIVQLINTRQPQAKIIVLGLLPRGEKPNPLRQKNAKVNQLLKVSLPKLANVQLLDIDGGFVHSDGAISCHDMFDFLHLTGGGYAKICKPLHELIMQLLEETPEEKQTTIA
  
Inhibitor
Name:
BDBM154542
Synonyms:
5-(bromomethyl)-6-(4-(tert-butyl)phenyl)-2-(p-tolyl)-1-tosyl-1,2,3,6-tetrahydropyridine (JW1058)
Type:
Small organic molecule
Emp. Form.:
C30H34BrNO2S
Mol. Mass.:
552.565
SMILES:
Cc1ccc(cc1)C1CC=C(CBr)C(N1S(=O)(=O)c1ccc(C)cc1)c1ccc(cc1)C(C)(C)C |t:10|
Structure:
Search PDB for entries with ligand similarity: