Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 2 [C118L,A144C]
Ligand
BDBM154576
Substrate
n/a
Meas. Tech.
EMSA
pH
7.5±n/a
IC50
8e+2±n/a nM
Comments
extracted
Citation
Alexander, LT; Möbitz, H; Drueckes, P; Savitsky, P; Fedorov, O; Elkins, JM; Deane, CM; Cowan-Jacob, SW; Knapp, S Type II Inhibitors Targeting CDK2. ACS Chem Biol 10:2116-25 (2015) [PubMed] Article
More Info.:
Target
Name:
Cyclin-dependent kinase 2 [C118L,A144C]
Synonyms:
CDK2 | CDK2_HUMAN | CDKN2 | Cyclin-dependent protein kinase 2 variant (CDK2 C118L/A144C)
Type:
Protein
Mol. Mass.:
33980.25
Organism:
Homo sapiens (Human)
Description:
CDK2 mutant (C118L/A144C)
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFLHSHRVLHRDLKPQNLLINTEGAIKLCDFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL