Target
Cyclin-dependent kinase 2 [F80T]
Ligand
BDBM154577
Substrate
n/a
Meas. Tech.
EMSA
Temperature
576.3±0 K
IC50
7.1e+3±n/a nM
Citation
 Alexander, LTM÷bitz, HDrueckes, PSavitsky, PFedorov, OElkins, JMDeane, CMCowan-Jacob, SWKnapp, S Type II Inhibitors Targeting CDK2. ACS Chem Biol 10:2116-25 (2015) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2 [F80T]
Synonyms:
CDK2 | CDK2_HUMAN | CDKN2 | Cyclin-dependent protein kinase 2 (CDK2 F80T)
Type:
Protein
Mol. Mass.:
33892.10
Organism:
Homo sapiens (Human)
Description:
P24941[F80T]
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVTEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM154577
Synonyms:
K03859 (2)
Type:
Small organic molecule
Emp. Form.:
C30H29F3N6O3
Mol. Mass.:
578.5849
SMILES:
CN1CCN(Cc2ccc(NC(=O)c3cccc4cc(Oc5cc(NC(C)=O)ncn5)ccc34)cc2C(F)(F)F)CC1
Structure:
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