Reaction Details Report a problem with these data
Target
Aurora kinase B
Ligand
BDBM155572
Substrate
n/a
Meas. Tech.
Inhibitory Assay
pH
7.4±n/a
IC50
880±n/a nM
Comments
extracted
Citation
 Hirai, H; Sootome, H Method for enhancing anti-tumor effect of a microtubule-targeting drug, and a method for treatment of tumor US Patent  US9012475 Publication Date 4/21/2015 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM155572
Synonyms:
US10092556, Example 19 | US9012475, 19 | US9346787, 19
Type:
Small organic molecule
Emp. Form.:
C26H27ClF2N6O2
Mol. Mass.:
528.981
SMILES:
Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3F)C(=O)N3CCC3)ccc2F)n[nH]1
Structure:
Search PDB for entries with ligand similarity: