Reaction Details
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Transient receptor potential cation channel subfamily V member 3
Ligand
BDBM155777
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
IC50
310±n/a nM
Citation
Clapham, B; Cox, PB; Dart, MJ; Gomtsyan, A; Jinkerson, TK; Keddy, RG; Kort, ME; Kym, PR; Matulenko, M; Schmidt, RG; Villamil, CI; Voight, EA; Woller, KR TRPV3 modulators US Patent US9012651 Publication Date 4/21/2015 More Info.:
Target
Name:
Transient receptor potential cation channel subfamily V member 3
Synonyms:
TRPV3 | TRPV3_HUMAN | Transient receptor potential cation channel subfamily V member 3 (TRPV3) | Vanilloid receptor-like 3
Type:
Enzyme
Mol. Mass.:
90635.51
Organism:
Homo sapiens (Human)
Description:
Q8NET8
Residue:
790
Sequence:
MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTSPPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFEEVEEFPETSV
Inhibitor
Name:
BDBM155777
Synonyms:
US9012651, 216
Type:
Small organic molecule
Emp. Form.:
C18H26F4N2O
Mol. Mass.:
362.4055
SMILES:
CC(C)[C@H](CO)NCc1nc(ccc1F)C1CCC(CC1)C(F)(F)F |wU:3.5,(2.67,-7.7,;4,-6.93,;4,-5.39,;5.33,-7.7,;5.33,-9.24,;6.67,-10.01,;6.67,-6.93,;8,-7.7,;9.34,-6.93,;10.67,-7.7,;12,-6.93,;12,-5.39,;10.67,-4.62,;9.34,-5.39,;8,-4.62,;13.34,-7.7,;14.67,-6.93,;16,-7.7,;16,-9.24,;14.67,-10.01,;13.34,-9.24,;17.34,-10.01,;18.67,-10.78,;16.57,-11.34,;18.11,-8.68,)|
Structure:
