Reaction Details
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Report a problem with these dataTarget
Transient receptor potential cation channel subfamily V member 3
Ligand
BDBM155813
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
IC50
340±n/a nM
Citation
Clapham, B; Cox, PB; Dart, MJ; Gomtsyan, A; Jinkerson, TK; Keddy, RG; Kort, ME; Kym, PR; Matulenko, M; Schmidt, RG; Villamil, CI; Voight, EA; Woller, KR TRPV3 modulators US Patent US9012651 Publication Date 4/21/2015 More Info.:
Target
Name:
Transient receptor potential cation channel subfamily V member 3
Synonyms:
TRPV3 | TRPV3_HUMAN | Transient receptor potential cation channel subfamily V member 3 (TRPV3) | Vanilloid receptor-like 3
Type:
Enzyme
Mol. Mass.:
90635.51
Organism:
Homo sapiens (Human)
Description:
Q8NET8
Residue:
790
Sequence:
MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTSPPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFEEVEEFPETSV
Inhibitor
Name:
BDBM155813
Synonyms:
US9012651, 257
Type:
Small organic molecule
Emp. Form.:
C18H26F4N2O
Mol. Mass.:
362.4055
SMILES:
CC(C)[C@H](CO)NCc1nc(ccc1F)[C@H]1CC[C@H](CC1)C(F)(F)F |wU:18.22,15.15,3.5,(-6.49,.01,;-5.16,.78,;-5.16,2.32,;-3.82,.01,;-3.82,-1.53,;-2.49,-2.3,;-2.49,.78,;-1.16,.01,;.18,.78,;1.51,.01,;2.85,.78,;2.85,2.32,;1.51,3.09,;.18,2.32,;-1.16,3.09,;4.18,.01,;5.51,.78,;6.85,.01,;6.85,-1.53,;5.51,-2.3,;4.18,-1.53,;8.18,-2.3,;9.51,-3.07,;7.41,-3.63,;8.95,-.97,)|
Structure:
