Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM287088
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
12.7±n/a nM
Comments
extracted
Citation
 Cuberes-Altisent, MR; Corbera-Arjona, J; Diaz-Fernandez, JL; Almansa-Rosales, C Pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma ligands US Patent  US9567338 Publication Date 2/14/2017 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM287088
Synonyms:
N-(1-[2-(Piperidin-1- yl)ethyl]-1H-pyrazolo[3,4- d]pyrimidin-4-yl)-1- adamantylcarboxamide maleate | US9567338, 4
Type:
Small organic molecule
Emp. Form.:
C23H32N6O
Mol. Mass.:
408.5398
SMILES:
O=C(Nc1ncnc2n(CCN3CCCCC3)ncc12)C12CC3CC(CC(C3)C1)C2 |TLB:27:26:21.22.23:29,THB:25:26:21:23.24.29|
Structure:
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