Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM287093
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
24.4±n/a nM
Comments
extracted
Citation
 Cuberes-Altisent, MR; Corbera-Arjona, J; Diaz-Fernandez, JL; Almansa-Rosales, C Pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma ligands US Patent  US9567338 Publication Date 2/14/2017 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM287093
Synonyms:
N-(1-(2-(piperidin-1- yl)ethyl)-1H-pyrazolo[3,4- d]pyrimidin-4-yl)(1- noradamantylcarboxamide) maleate | US9567338, 11
Type:
Small organic molecule
Emp. Form.:
C22H30N6O
Mol. Mass.:
394.5132
SMILES:
O=C(Nc1ncnc2n(CCN3CCCCC3)ncc12)C12CC3CC1CC(C2)C3 |TLB:21:20:22.28.23:25,27:26:23:20.21,1:20:23:28.26.25,THB:21:22:20.27:25,27:20:23:28.26.25,1:20:22.28.23:25|
Structure:
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