Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM287103
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
15.0±n/a nM
Comments
extracted
Citation
 Cuberes-Altisent, MR; Corbera-Arjona, J; Diaz-Fernandez, JL; Almansa-Rosales, C Pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma ligands US Patent  US9567338 Publication Date 2/14/2017 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM287103
Synonyms:
N-(1-(2-(Azepan-1- yl)ethyl)-1H-pyrazolo[3,4- d]pyrimidin-4-yl) 1- noradamantylcarboxamide hydrochloride | US9567338, 22
Type:
Small organic molecule
Emp. Form.:
C23H30N6O
Mol. Mass.:
406.5239
SMILES:
O=C(Nc1ncnc2n(CCN3CCCCCC3)ncc12)C12C3CC11CC2CC1C3 |TLB:23:22:26.27:24,25:26:29.22:24,1:21:28.29:23,1:21:28.27:25,THB:22:21:28.27:25,26:21:28.29:23,27:28:21:23,29:28:21:25,(-4.43,3.12,;-3.1,3.89,;-1.77,3.12,;-1.77,1.58,;-3.1,.81,;-3.1,-.73,;-1.77,-1.5,;-.43,-.73,;1.03,-1.2,;1.43,-2.69,;2.92,-3.09,;3.32,-4.58,;2.11,-5.54,;2.11,-7.08,;3.32,-8.04,;4.82,-7.69,;5.49,-6.31,;4.82,-4.92,;1.94,.04,;1.03,1.29,;-.43,.81,;-3.1,5.43,;-5.49,6.79,;-4.58,5.55,;-3.12,6.02,;-1.65,5.55,;-.75,6.79,;-1.65,8.04,;-3.12,7.56,;-4.58,8.04,)|
Structure:
Search PDB for entries with ligand similarity: