Reaction Details Report a problem with these data
Target
Rhomboid protease GlpG
Ligand
BDBM165195
Substrate
n/a
Meas. Tech.
Activity-based Protein Profiling (ABPP)
pH
7.4±0
Temperature
310.15±0 K
IC50
6.5e+4± 9e+3 nM
Citation
 Wolf, EV; Zeissler, A; Verhelst, SH Inhibitor Fingerprinting of Rhomboid Proteases by Activity-Based Protein Profiling Reveals Inhibitor Selectivity and Rhomboid Autoprocessing. ACS Chem Biol 10:2325-33 (2015) [PubMed]  Article 
Target
Name:
Rhomboid protease GlpG
Synonyms:
Rhomboid protease (HiGlpG)
Type:
Protein
Mol. Mass.:
21622.69
Organism:
Haemophilus influenzae (g-Proteobacteria)
Description:
n/a
Residue:
192
Sequence:
MKNFLAQQGKITLILTALCVLIYLAQQLGFEDDIMYLMHYPAYEEQDSEVWRYISHTLVHLSNLHILFNLSWFLIFGGMIERTFGSVKLLMLYVVASAITGYVQNYVSGPAFFGLSGVVYAVLGYVFIRDKLNHHLFDLPEGFFTMLLVGIALGFISPLFGVEMGNAAHISGLIVGLIWGFIDSKLRKNSLE
  
Inhibitor
Name:
BDBM165195
Synonyms:
(4S)‐4‐(pent‐4‐yn‐1‐yl)‐3‐(3,4,5‐trimethoxyphenyl)oxetan‐2‐one (45)
Type:
Small organic molecule
Emp. Form.:
C17H20O5
Mol. Mass.:
304.3377
SMILES:
COc1cc(cc(OC)c1OC)[C@H]1[C@H](CCCC#C)OC1=O |r|
Structure:
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