Reaction Details Report a problem with these data
Target
Rhomboid domain-containing protein
Ligand
BDBM165197
Substrate
n/a
Meas. Tech.
Activity-based Protein Profiling (ABPP)
pH
7.4±0
Temperature
310.15±0 K
IC50
4.8e+4± 1.0e+4 nM
Citation
 Wolf, EV; Zeissler, A; Verhelst, SH Inhibitor Fingerprinting of Rhomboid Proteases by Activity-Based Protein Profiling Reveals Inhibitor Selectivity and Rhomboid Autoprocessing. ACS Chem Biol 10:2325-33 (2015) [PubMed]  Article 
Target
Name:
Rhomboid domain-containing protein
Synonyms:
Rhomboid protease (TmROM)
Type:
Protein
Mol. Mass.:
26404.64
Organism:
Thermotoga maritima (Thermotogales)
Description:
Q9WZ53
Residue:
235
Sequence:
MRKRAVYFILLFNAFIFVMMTFSGVFSTRDPVLQMLLLLRYGAQYGPRVDAGDWFRLITALFVHGGILHILFNSYALYYFGLIVEDIYGTEKFLVGYFFTGIVGNLATHVFYHDTISVGASGAIFGLIGILFAAGFRKDTPFFMKPVTGVSLLPIILINVVYGFLPGTNINNAAHLGGFLSGMLLGYTMSPFSWKRRTLWRVLAIAVVLLVVLSYIFLIRQIPEIDEAIRRFKAG
  
Inhibitor
Name:
BDBM165197
Synonyms:
(4S)‐3‐butyl‐4‐(pent‐4‐yn‐1‐yl)oxetan‐2‐one (48)
Type:
Small organic molecule
Emp. Form.:
C12H18O2
Mol. Mass.:
194.2701
SMILES:
CCCC[C@H]1[C@H](CCCC#C)OC1=O |r|
Structure:
Search PDB for entries with ligand similarity: