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Target
Rhomboid protease GlpG
Ligand
BDBM165197
Substrate
n/a
Meas. Tech.
Activity-based Protein Profiling (ABPP)
pH
7.4±0
Temperature
310.15±0 K
IC50
4.4e+4± 6e+3 nM
Citation
 Wolf, EV; Zeissler, A; Verhelst, SH Inhibitor Fingerprinting of Rhomboid Proteases by Activity-Based Protein Profiling Reveals Inhibitor Selectivity and Rhomboid Autoprocessing. ACS Chem Biol 10:2325-33 (2015) [PubMed]  Article 
Target
Name:
Rhomboid protease GlpG
Synonyms:
GLPG_ECOLI | Rhomboid protease (EcGlpG) | glpG
Type:
Protein
Mol. Mass.:
31313.89
Organism:
Escherichia coli (Enterobacteria)
Description:
P09391
Residue:
276
Sequence:
MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLENPADPRYLAASWQAGHTGSGLHYRRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK
  
Inhibitor
Name:
BDBM165197
Synonyms:
(4S)‐3‐butyl‐4‐(pent‐4‐yn‐1‐yl)oxetan‐2‐one (48)
Type:
Small organic molecule
Emp. Form.:
C12H18O2
Mol. Mass.:
194.2701
SMILES:
CCCC[C@H]1[C@H](CCCC#C)OC1=O |r|
Structure:
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