Reaction Details Report a problem with these data
Target
N-glycosylase/DNA lyase
Ligand
BDBM163680
Substrate
n/a
Meas. Tech.
Fluorescence-based Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
3.7e+2± 2e+1 nM
Comments
extracted
Citation
 Donley, N; Jaruga, P; Coskun, E; Dizdaroglu, M; McCullough, AK; Lloyd, RS Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). ACS Chem Biol 10:2334-43 (2015) [PubMed]  Article 
Target
Name:
N-glycosylase/DNA lyase
Synonyms:
8-Oxoguanine DNA glycosylase-1 (OGG1) | MMH | MUTM | OGG1 | OGG1_HUMAN | OGH1
Type:
Protein
Mol. Mass.:
38794.33
Organism:
Homo sapiens (Human)
Description:
O15527
Residue:
345
Sequence:
MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG
  
Inhibitor
Name:
BDBM163680
Synonyms:
3‐Chloro‐N'‐[(1Z)‐2‐methylcyclohexylidene]‐1‐ benzothiophene‐2‐carbohydrazide (0154)
Type:
Small organic molecule
Emp. Form.:
C16H17ClN2OS
Mol. Mass.:
320.837
SMILES:
CC1CCCC\C1=N\NC(=O)c1sc2ccccc2c1Cl
Structure:
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