Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 1
Ligand
BDBM164884
Substrate
n/a
Meas. Tech.
In Vitro Kinase Inhibition Assay
pH
7.5±n/a
IC50
1877±n/a nM
Comments
extracted
Citation
 Zeitlmann, L; Niestroj, A; Heiser, U Inhibitors of protein kinases US Patent  US9067888 Publication Date 6/30/2015 
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
  
Inhibitor
Name:
BDBM164884
Synonyms:
US9067888, 34
Type:
Small organic molecule
Emp. Form.:
C20H22FN3O3
Mol. Mass.:
371.4054
SMILES:
COc1cc(F)ccc1-c1ccnc(NC(=O)C2CCC(C2)NC(C)=O)c1
Structure:
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