Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM165922
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
277.15±n/a K
Ki
24±n/a nM
Comments
extracted
Citation
 Luithle, J; Boess, F; Erb, C; Hafner, F; Schnizler, K; Flessner, T; Van Kampen, M; Van Der Staay, F 2-heteroaryl carboxamides US Patent  US9067931 Publication Date 6/30/2015 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM165922
Synonyms:
US10214524, Example 4 | US9067931, 4
Type:
Small organic molecule
Emp. Form.:
C26H29N3O3
Mol. Mass.:
431.5268
SMILES:
O=C(N[C@H]1CN2CCC1CC2)c1cc2ccc(cc2o1)-c1ccc(cc1)N1CCOCC1 |r,wU:3.2,(-4.99,-2.36,;-4.99,-.82,;-6.33,-.05,;-7.66,-.82,;-7.66,-2.36,;-8.99,-3.13,;-10.33,-2.36,;-10.33,-.82,;-8.99,-.05,;-8.22,-1.39,;-9.71,-1.79,;-3.66,-.05,;-3.5,1.48,;-1.99,1.8,;-1.22,3.13,;.32,3.13,;1.09,1.8,;.32,.47,;-1.22,.47,;-2.25,-.68,;2.63,1.8,;3.4,.47,;4.94,.47,;5.71,1.8,;4.94,3.13,;3.4,3.13,;7.25,1.8,;8.02,.47,;9.56,.47,;10.33,1.8,;9.56,3.13,;8.02,3.13,)|
Structure:
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