Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM165936
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
277.15±n/a K
Ki
14±n/a nM
Comments
extracted
Citation
 Luithle, J; Boess, F; Erb, C; Hafner, F; Schnizler, K; Flessner, T; Van Kampen, M; Van Der Staay, F 2-heteroaryl carboxamides US Patent  US9067931 Publication Date 6/30/2015 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM165936
Synonyms:
US10214524, Example 163 | US9067931, 163
Type:
Small organic molecule
Emp. Form.:
C28H32N4O3
Mol. Mass.:
472.5787
SMILES:
CN1CCN(CC1)C(=O)c1cccc(c1)-c1cccc2cc(oc12)C(=O)N[C@H]1CN2CCC1CC2 |r,wU:27.30,(9.17,-5.33,;8.4,-4,;6.86,-4,;6.09,-2.67,;6.86,-1.33,;8.4,-1.33,;9.17,-2.67,;6.09,,;6.86,1.33,;4.55,,;3.78,-1.33,;2.24,-1.33,;1.47,,;2.24,1.33,;3.78,1.33,;1.47,2.67,;2.24,4,;1.47,5.33,;-.07,5.33,;-.84,4,;-2.34,3.68,;-2.5,2.15,;-1.1,1.52,;-.07,2.67,;-3.84,1.38,;-3.84,-.16,;-5.17,2.15,;-6.51,1.38,;-6.51,-.16,;-7.84,-.93,;-9.17,-.16,;-9.17,1.38,;-7.84,2.15,;-7.07,.82,;-8.63,.28,)|
Structure:
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