Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM167340
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7±n/a
IC50
1800±n/a nM
Comments
extracted
Citation
 Gillespie, P Benzoic acid derivatives US Patent  US9073881 Publication Date 7/7/2015 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN
Type:
Protein
Mol. Mass.:
25095.44
Organism:
Homo sapiens (Human)
Description:
P06730
Residue:
217
Sequence:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM167340
Synonyms:
US9073881, 90
Type:
Small organic molecule
Emp. Form.:
C23H14Cl3NO3S
Mol. Mass.:
490.786
SMILES:
COc1cccc(Cl)c1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 |(-1.77,-9.77,;-1.77,-8.13,;-3.19,-7.31,;-4.52,-8.08,;-5.86,-7.31,;-5.86,-5.77,;-4.52,-5,;-4.52,-3.35,;-3.19,-5.77,;-1.86,-5,;-.52,-5.77,;.81,-5,;.81,-3.46,;-.52,-2.69,;-1.86,-3.46,;-2.81,-2.3,;-2.03,-.97,;-4.35,-2.3,;2.14,-2.69,;3.61,-3.16,;4.51,-1.92,;3.61,-.67,;2.14,-1.15,;6.05,-1.92,;6.82,-3.25,;8.36,-3.25,;9.13,-1.92,;10.67,-1.92,;8.36,-.58,;9.19,.84,;6.82,-.58,)|
Structure:
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