Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM167388
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7±n/a
IC50
700±n/a nM
Comments
extracted
Citation
 Gillespie, P Benzoic acid derivatives US Patent  US9073881 Publication Date 7/7/2015 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN
Type:
Protein
Mol. Mass.:
25095.44
Organism:
Homo sapiens (Human)
Description:
P06730
Residue:
217
Sequence:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM167388
Synonyms:
US9073881, 140
Type:
Small organic molecule
Emp. Form.:
C23H13Cl3FNO2S
Mol. Mass.:
492.777
SMILES:
Cc1ccc(Cl)c(c1F)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 |(-5.19,-9.44,;-5.19,-7.9,;-6.53,-7.13,;-6.53,-5.59,;-5.19,-4.82,;-5.19,-3.28,;-3.86,-5.59,;-3.86,-7.13,;-2.52,-7.9,;-2.52,-4.82,;-1.19,-5.59,;.14,-4.82,;.14,-3.28,;-1.19,-2.51,;-2.53,-3.28,;-3.25,-2.19,;-2.49,-.85,;-4.79,-2.19,;1.48,-2.51,;2.94,-2.98,;3.85,-1.74,;2.94,-.49,;1.48,-.97,;5.39,-1.74,;6.16,-3.07,;7.7,-3.07,;8.47,-1.74,;10.01,-1.74,;7.7,-.4,;8.47,.93,;6.16,-.4,)|
Structure:
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