Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM167877
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
123±n/a nM
Comments
extracted
Citation
 Guzzo, PR; Surman, MD; Zhu, L Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof US Patent  US9073925 Publication Date 7/7/2015 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM167877
Synonyms:
US9073925, 6
Type:
Small organic molecule
Emp. Form.:
C26H23F3N4O
Mol. Mass.:
464.4822
SMILES:
Cn1c2C3CCN(CC3)Cc2c2ccc(cc12)-n1ccc(cc1=O)-c1ccc(cn1)C(F)(F)F |(5.78,-1.2,;5.01,.13,;5.91,1.38,;7.45,1.38,;8.46,2.54,;8.19,4.05,;6.83,4.78,;6.29,3.67,;7.45,2.68,;5.42,4.18,;5.01,2.62,;3.54,2.15,;2.21,2.92,;.87,2.15,;.87,.61,;2.21,-.16,;3.54,.61,;-.46,-.16,;-.46,-1.7,;-1.79,-2.47,;-3.13,-1.7,;-3.13,-.16,;-1.79,.61,;-1.79,2.15,;-4.46,-2.47,;-5.79,-1.7,;-7.13,-2.47,;-7.13,-4.01,;-5.79,-4.78,;-4.46,-4.01,;-8.46,-4.78,;-9.8,-5.55,;-9.8,-4.01,;-8.46,-6.32,)|
Structure:
Search PDB for entries with ligand similarity: